Table 6.
Differential expression of genes related to lipid and sterol metabolism
| Gene ID 1 | Annotation 2 | Mean fold change± SE 3 | Identity 4 |
|---|---|---|---|
| Ssa#S18890165 |
CB515874 |
23.2 ± 2.2 |
Creatine kinase, ubiquitous mitochondrial precursor |
| Ssa#STIR00012_4 |
AY848944 |
13.3 ± 1.1 |
Prostaglandin-endoperoxide synthase 2 |
| Ssa#S30259776 |
DW546744 |
8.7 ± 0.3 |
Sphingomyelin synthase 1 |
| Ssa#STIR22551 |
TC84899 |
6.3 ± 0.2 |
Lipoprotein lipase |
| Ssa#TC105353 |
TC105353 |
5.5 ± 1.0 |
Mecr protein |
| Ssa#STIR12701 |
TC70393 |
3.6 ± 0.1 |
Retinol dehydrogenase 3 |
| Ssa#STIR31819 |
TC98944 |
3.5 ± 0.3 |
Glucose-6-phosphate-1-dehydrogenase |
| Ssa#S48420588 |
NM_001173773 |
3.2 ± 0.7 |
Myotubularin |
| Ssa#S31962884 |
DY691674 |
2.9 ± 0.1 |
Cytochrome c oxidase subunit 5B, mitochondrial |
| Ssa#S31963491 |
DY692281 |
2.8 ± 0.1 |
PPAR-alpha interacting complex protein 285 isoform 1 |
| Ssa#KSS1976 |
KSS1976 |
2.8 ± 0.2 |
78 kDa glucose-regulated protein |
| Ssa#S35587721 |
EG874099 |
2.7 ± 0.2 |
Apolipoprotein-L3 |
| Ssa#S30242761 |
DW538822 |
2.6 ± 0.2 |
Glycolipid transfer protein |
| Ssa#S32012431 |
DY741028 |
2.3 ± 0.1 |
StAR-related lipid transfer domain containing 3 |
| Ssa#CL50Contig2 |
CL50Contig2 |
2.3 ± 0.1 |
Fructose-bisphosphate aldolase A |
| Ssa#S32007249 |
DY735846 |
2.1 ± 0.2 |
Adipose differentiation-related protein |
| Ssa#STIR13627 |
TC71700 |
−2.0 ± 0.2 |
Cox18 cytochrome c oxidase assembly homolog |
| Ssa#CA043659 |
CA043659 |
−2.1 ± 0.2 |
Apolipoprotein B precursor |
| Ssa#DW564686 |
DW564686 |
−2.1 ± 0.1 |
Mitochondrial uncoupling protein 2 |
| Ssa#STIR21893 |
TC83911 |
−2.2 ± 0.1 |
Creatine kinase b-type |
| Ssa#S35679641 |
EG914359 |
−2.5 ± 0.1 |
Lipid phosphate phosphohydrolase 1 |
| Ssa#STIR22405 |
TC84675 |
−2.6 ± 0.1 |
Lipase a |
| Ssa#S30285553 |
DW572521 |
−2.6 ± 0.1 |
Lipid phosphate phosphohydrolase 2 |
| Ssa#S30246050 |
DW542111 |
−2.9 ± 0.3 |
Glyceraldehyde-3-phosphate dehydrogenase-2 |
| Ssa#TC108704 |
TC108704 |
−3.8 ± 0.2 |
Lipocalin precursor |
| Ssa#STIR21285 |
TC82989 |
−4.9 ± 0.3 |
Glutamine synthetase |
| Ssa#S35523399 |
EG809777 |
−5.2 ± 0.5 |
Cholesteryl ester transfer protein, plasma |
| Ssa#STIR22650 | TC85053 | −5.2 ± 1.4 | Apolipoprotein a-i binding protein |
List of selected mRNAs related to the lipid & sterol metabolism found to be increased or decreased in expression in response to rIL-1β stimulation. Genes were assigned to the table based upon both their GO identifier and previous knowledge of their functions. Genes with greatest fold differences in expression are presented, the genes that are lower in expression are denoted by (-) value. The genes shown were significant at p < 0.05 following t- tests with Benjamini-Hochberg FDR and greater than 2-fold change. 1Indicates the unique code for the feature on the microarray, 2Accession number of the cDNA sequence, accession numbers beginning with TC are for oligos from the TIGR Atlantic Salmon Gene Index. 3Fold change, in the case of oligos that featured multiple times in the gene list the one with the highest fold change is reported. 4Identity of the probe target as determined by BLASTX and BLASTN searches.