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Hsp90 inhibition decreases SEB-induced T lymphocyte IFN-γ production and cellular activation. Human CD3+ T lymphocytes stimulated with SEB (1 μg/ml) were treated with geldanamycin and then evaluated for intracellular IFN-γ production and cell activation by flow cytometry. Hsp90 inhibition resulted in a dramatic decrease in IFN-γ production and activation (CD69+) in both CD4+ and CD8+ T lymphocyte subsets.
