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Mediation analysis.
| Genotype dataset | Enzyme | SNP effect | No. of sig. trios P < 10−5 |
No. of sig. SNPs P < 10−5 |
No. of sig. exp P < 10−5 |
FDR (trios) |
|---|---|---|---|---|---|---|
| Affymetrix | CYP2D6 | Gene dose | 389,573 | 103,369 | 3,545 | 16.63% |
| Illumina array | CYP2D6 | Gene dose | 1,214,416 | 251,738 | 4,770 | 11.73% |
