Fig. 4. These mice were preconditioned for 2 days without drug treatment. Then quetiapine quetiapine (A) 0.1 mg/kg, (B) 0.5 mg/kg or (C) 1.0 mg/kg), i.p., saline ((-) control, 1 ml, i.p.) and methamphetamine ((+) control, 1 mg/kg, i.p.) were administered to the mice once a day for 8 days. Place preference was measured on the next day after the conditioning period. Data are expressed as mean ± S.E. (n=10). ^*p<0.05, compared with saline treated group.