Table 3.

Predicted effect of missense gene variants on SAT1 protein structure stability, and allelic frequencies of these variants in the NCBI SNP database.

SLC26A1 variant	aStability prediction	bSVM score	Allelic frequency this study	Allelic frequency cNCBI database	cNCBI SNP accession
M132T	decrease	−0.9	0.038	—	—
R372H	decrease	−1.0	0.038	0.0082	rs73219719
Q556R	increase	0.2	0.307	0.3484	rs3796622

^aPrediction of protein stability and ^bSupport Vector Machine modelling scores (values less than zero are significant) [10]. ^cNCBI database accessed on October 30 2012.