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. Author manuscript; available in PMC: 2013 Nov 7.
Published in final edited form as: Neuropharmacology. 2009 Feb 5;56(0):10.1016/j.neuropharm.2009.01.020. doi: 10.1016/j.neuropharm.2009.01.020

Figure 9. Effect of pretreatment times for PG01037 on apomorphine-dependent AIMs in lesioned rats.

Figure 9

(A) Unilaterally lesioned rats were treated with PG01037 (10 mg/kg) at varying times (30, 20, 10 and 0 minutes) prior to the administration of apomorphine (0.05 mg/kg, s.c.). The mean normalized values for the total AIM scores ± S.E.M. are shown relative to the values obtained from animals injected with vehicle. The number of animals (n) for each pretreatment time is as follows: a) 0 minutes, n = 12, b) 10 minutes, n = 6, c) 20 minutes, n = 5 and d) 30 minutes, n = 6. Similar plots for the total AIMs score are essentially identical to those shown in this figure. Although there was no significant reduction of the total AIMs score at the 30 and 20 minute pretreatment times, there was significant reduction when PG01037 was administered at 10 minutes (p < 0.01) and 0 minute (p < 0.0001) prior to the administration of L-dopa. The normalized mean total AIMs activity for animals administered PG01037 at zero minutes prior to apomorphine administration is 61.9 ± 4.4% of vehicle control values. (B) The variation in the total AIMs score as a function of time is shown using zero time pretreatment with 10 mg/kg PG01037 (●) or vehicle control (○). Animals were also injected (s.c.) with 0.05 mg/kg apomorphine. Each point is the summation of total AIM scores for a total of 12 animals at each observation time point. This represents a mean 38.1 ± 4.4 (S.E.M.) percent reduction in the total AIMs score over the observation time. Plots of the summation of the AIMs score minus the locomotor component are essentially identical in shape with a 38.8 ± 4.1 percent reduction in the AIMs minus locomotor component.