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. Author manuscript; available in PMC: 2013 Nov 7.
Published in final edited form as: J Psychopharmacol. 2012 Oct 26;27(4):10.1177/0269881112463468. doi: 10.1177/0269881112463468

Figure 6.

Figure 6

Reelin rescues the sensorimotor gating deficit observed in HRM as tested by acoustic pre-pulse inhibition (PPI). Mice received a single bilateral ventricular injection of either mock (black; n = 10) or Reelin (white; n = 9). Normal wild-type littermate control observations are shown in red (n = 8). Acoustic startle and PPI to acoustic startle were given to determine sensorimotor gating ability 5 days post-injection. (a) There were no significant differences of acoustic startle reflex in HRM given a 120 dB pulse between experimental groups. (b) Reelin increased the percent inhibition to 78, 86 and 90 dB pre-pulse compared with mock-injected mice.