Table 2.
Toxicities Noted During Fenretinide Therapy Reported As Related to the Treatment
| Toxicity | Grade 1 | Grade 2 | Grade 5 |
|---|---|---|---|
| Abdominal pain | 2 | 0 | 0 |
| Abdominal cramping | 1 | 0 | 0 |
| Alopecia | 1 | 0 | 0 |
| Amylase increase | 1 | 0 | 0 |
| Anemia | 4 | 0 | 0 |
| Bleeding (without grade 3 or 4 thrombocytopenia) | 0 | 0 | 1 |
| CNS bleeding* | 0 | 0 | 0 |
| Cognitive disturbance | 2 | 0 | 0 |
| Confusion | 0 | 2 | 0 |
| Constipation | 1 | 0 | 0 |
| Diarrhea | 3 | 1 | 0 |
| Dizziness | 4 | 0 | 0 |
| Dry skin | 3 | 1 | 0 |
| Edema | 1 | 0 | 0 |
| Elevated transaminases | 2 | 0 | 0 |
| Elevated lactate dehydrogenase | 1 | 0 | 0 |
| Erythema multiforme | 0 | 1 | 0 |
| Fatigue | 8 | 3 | 0 |
| Headache | 3 | 0 | 0 |
| Hypercholesterolemia | 2 | 0 | 0 |
| Hypertriglyceridemia | 1 | 0 | 0 |
| Hypoalbuminemia | 3 | 0 | 0 |
| Hypokalemia | 1 | 0 | 0 |
| Hyponatremia | 1 | 0 | 0 |
| Hypophosphatemia | 0 | 1 | 0 |
| Infection without neutropenia | 0 | 1 | 0 |
| Insomnia | 2 | 0 | 0 |
| Leukopenia | 3 | 0 | 0 |
| Lymphocytopenia | 1 | 1 | 0 |
| Muscle weakness | 0 | 1 | 0 |
| Nausea or vomiting† | 2 | 1 | 0 |
| Night blindness | 1 | 0 | 0 |
| Photoposia | 1 | 0 | 0 |
| Pruritus | 1 | 0 | 0 |
| Seizures | 0 | 1 | 0 |
| Skin rash | 2 | 1 | 0 |
| Speech impairment | 0 | 1 | 0 |
| Stomatitis | 1 | 0 | 0 |
| Thrombocytopenia | 3 | 0 | 0 |
| Watery eyes | 2 | 0 | 0 |
| Xerostomia | 3 | 0 | 0 |
| Total | 67 | 16 | 1 |
*
Grade 3 and grade 4 CNS hemorrhage (intratumoral bleeding) was noted in one patient each.
†
One patient had grade 3 nausea.