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. Author manuscript; available in PMC: 2014 Mar 18.
Published in final edited form as: Nat Commun. 2013;4:2490. doi: 10.1038/ncomms3490

Figure 5.

Figure 5

The Met66 prodomain induces growth cone retraction in cultured hippocampal neurons. (a) Neurons were treated with Val66 or Met66 prodomains (10 ng/ml) for 20 min, fixed, and stained for actin and p75NTR. Arrows indicate retracted growth cones; asterisks indicate intact growth cones. Scale bar: 20 μm. (b) Quantification of growth cone retraction in p75NTR positive cells shown in (a), compared to p75NTR negative cells. Prodomain abbreviated as prod. (b) n= 4 independent experiments. Bars represent mean ± s.e.m. Statistical comparisons were made by one way analysis of variance test. * p <0.05.