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. 2013 Aug 15;6(6):1477–1486. doi: 10.1242/dmm.012328

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — EAG phenotypes and autoantibody responses in parental (WKY and LEW) and double congenic (LEW.WCrgn1,2) rat strains at day 28. (A) Percentage of glomeruli with crescents. (B) Macrophage infiltration quantified by the percentage of ED1+ cells per glomerular cross-section. (C) Measurement of proteinuria. (D) Serum circulating anti-GBM antibody levels, showing similar serological autoimmunity in all three strains. (E) Quantification of deposited anti-GBM antibody (graded 0 to 3+ intensity) in each rat strain assessed by direct immunofluorescence (IF) for anti-rat immunoglobulins. (A–E) Statistically significant differences in mean values between the LEW.WCrgn1,2 strain and LEW strain compared using a one-way ANOVA with Newman-Keuls comparison test. ns: non-significant. WKY and LEW rats, n=6; LEW.WCrgn1,2 rats, n=10. (F) Representative direct immunofluorescence images showing pattern and intensity of anti-GBM antibody deposition in glomeruli in each rat strain.