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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Clin Pharmacol Ther. 2013 May 29;94(3):400–406. doi: 10.1038/clpt.2013.114

Table 3.

Half-Life Estimates by Sex, Race and Age

N Half-Life
Point Estimate
(95% CI)
Creatinine-corrected
Half-Life
Point Estimate
(95% CI)
Creatinine-uncorrected
All subjects 49* 17.9 (16.5, 19.3) 17.9 (16.5, 19.3)
Sex Male 25* 18.4 (17.1, 19.7) 18.5 (17.1, 19.9)
        Female 24 17.4 (15.2, 19.6) 17.4 (14.8, 19.6)
Race
White# 12 17.5 (15.5, 19.5) 17.7 (15.3, 20.1)
Black 29* 18.1 (16.4, 19.8) 17.7 (15.9, 19.5)
Mixed 8 18.2 (15.4, 21.0) 18.8 (14.1, 23.5)
Age Groups
< 1 year old (y.o.) 11 15.7 (13.6, 17.8) 13.7 (12.0, 15.4)
1–1.9 y.o. 7* 18.5 (15.9, 21.1) 18.4 (16.3, 20.5)
2–2.9 y.o. 8 18.5 (15.6, 21.4) 10.5 (7.0, 14.0)
3–3.9 y.o. 8 17.2 (13.6, 20.8) 16.8 (13.6, 20.6)
4–4.9 y.o. 7 18.6 (15.7, 21.5) 20.0 (16.0, 24.0)
5–6 y.o. 8 19.3 (16.8, 21.8) 19.6 (16.4, 22.8)
*

One 18-month old black male was excluded from the creatinine corrected urine half-life calculation because of missing creatinine levels, for a total of 48 subjects with the creatinine corrected results.

#

Included Hispanic-Whites