Table 2.

Time course of major symptoms and signs

	Baseline				Week 10
	Intensity of				Intensity of
	Spontaneous pain*	Itching*	Sleep disorder†	Difficulty in walking	Spontaneous pain*	Itching*	Sleep disorder†	Difficulty in walking
Repellent group
Patient R.R.	4	2	Yes	Yes	0	0	No	No
Patient M.R.	0	1	Yes	No	0	0	No	No
Patient M.F.R.	3	2	Yes	Yes	0	0	No	No
Patient J.F.R.	1	0	Yes	Yes	0	0	No	No
Median; n/N	2	1.5	4/4	3/4	0	0	0/4	0/4
Shoe group
Patient E.R.	2	2	Yes	Yes	0	0	No	No
Patient J.R.	4	4	Yes	Yes	2	2	Yes	No
Patient Z.R.	0	0	No	Yes	0	0	No	No
Patient M.R.	3	2	Yes	Yes	2	2	Yes	No
Median; n/N	2.5	2.0	3/4	4/4	1	1	2/4	0/4

^*Assessed semi-quantitatively: 0 (no pain/no itching) to 4 (the worst imaginable pain/the worst imaginable itching); see Electronic Supplementary Material.

^†Because of pain and/or itching.