Table 1. Case–control study of severe falciparum malaria for association with the SNP rs10900589 of the ATPase, Ca++ transporting, plasma membrane 4 (ATP2B4) gene.
| MAF | n | Pdom | Padd | Prec | Pmax | OR01 (95% CI)a | OR02 (95% CI)b | Modelc | |
|---|---|---|---|---|---|---|---|---|---|
| Ghanaian GWAS group | 0.35 | 2147 | 1.0E-01 | 6.8E-04 | 9.5E-06 | 2.1E-05 | 0.96 (0.80;1.16) | 0.53 (0.41;0.70) | REC |
| Ghanaian replication group | 0.37 | 3474 | 2.3E-03 | 7.4E-05 | 3.8E-04 | 1.3E-04 | 0.85 (0.73;0.98) | 0.61 (0.49:0.77) | ADD |
| Ghanaian groups combined | 0.36 | 5621 | 6.7E-04 | 1.8E-07 | 3.4E-08 | 2.1E-08 | 0.89 (0.79;0.99) | 0.58 (0.49;0.69) | REC |
| Gambian GWAS group | 0.28 | 2209 | 5.7E-01 | 4.1E-01 | 2.8E-03 | 4.6E-03 | 1.06 (0.89;1.26) | 0.69 (0.49;0.96) | REC |
| Combined analysis of all three groups | 0.34 | 7830 | 2.9E-02 | 9.9E-06 | 8.1E-09 | 2.0E-08 | 0.95 (0.87;1.05) | 0.63 (0.54;0.73) | REC |
Abbreviations: CI, confidence interval; MAF, minor allele frequency; n, sample size; OR, odds ratio; Pdom, P-value for dominant mode of inheritance (MOI); Padd, P-value for additive MOI; Prec, P-value for recessive MOI; Pmax, P-value of MAX test.
a
Genotypic OR and 95% CI for one compared with zero risk alleles.
b
Genotypic OR and 95% CI for two compared with zero risk alleles.
c
Model selected by MAX test procedure: DOM, dominant, ADD, additive, REC, recessive.