Table 1.
Identified potential substrates of hepatic forms of OATPs with pharmacological interest.
| OATP1B1 | OATP1B3 | OATP1A2 | |
|---|---|---|---|
| Substrates | Benzylpenicillin | ||
| Bile acid derivatives (BAMETS) | Bile acid derivatives (BAMETS) | Bile acid derivatives (BAMETS) | |
| Bilirubin and its conjugates | Bilirubin conjugates | ||
| Bosentan | Bosentan | ||
| BQ-123 | BQ-123 | BQ-123 | |
| Bromosulfophthalein | Bromosulfophthalein | Bromosulfophthalein | |
| Caspofungin | |||
| Cerivastatin | Cholecystokinin-8 | ||
| Cholic acid | Cholic acid | ||
| DHEA sulphate | DHEA sulphate | DHEA sulphate | |
| Deltorphin II | Deltophorin II | ||
| Digoxin | |||
| DPDPE | DPDPE | DPDPE | |
| Docetaxel | |||
| Enalapril | Enalapril | ||
| Estradiol 17β-glucuronide | Estradiol 17β-glucuronide | ||
| Estrone-3-sulphate | Estrone-3-sulphate | ||
| Fexofenadine | Fexofenadine | ||
| Flavopiridol | Flavopiridol | ||
| Fluvastatin | Fluvastatin | ||
| Glycocholate | Glycocholate | Glycocholate | |
| Irinotecan and SN-38 | Irinotecan and SN-38 | ||
| Imatinib | |||
| Levofloxacin | |||
| Leukotriene C4 | Leukotriene C4 | ||
| Methotrexate | Methotrexate | Methotrexate | |
| Microcystin-LR | Microcystin-LR | Microcystin-LR | |
| Olmesartan | Olmesartan | ||
| Ouabain | Ouabain | ||
| Paclitaxel | Paclitaxel | ||
| Phalloidin | Phalloidin | ||
| D-Penicillamine | |||
| Pravastatin | Pravastatin | ||
| Prostaglandin E2 | Prostaglandin E2 | ||
| Rifampicin | Rifampicin | ||
| Rosuvastatin | Rosuvastatin | Rosuvastatin | |
| Saquinavir | |||
| Taurocholate | Taurocholate | Taurocholate | |
| Telmisartan | |||
| Thromboxane B2 | |||
| Thyroxine | Thyroxine | Thyroxine | |
| Triiodothyronine | Triiodothyronine | Triiodothyronine | |
| Troglitazone sulphate | |||
| Valsartan | Valsartan |