Table 1. Cten staining and clinicopathological characteristics of 445 melanoma patients.
|
Cten staining
|
|
|||
|---|---|---|---|---|
| Variables | Neg-Mod | Strong | Total | P-value1 |
| Primary Melanoma (n=297) | ||||
| Age | ||||
| ≤60 | 85 (58.2%) | 61 (41.8%) | 146 | 0.808 |
| >60 | 90 (59.6%) | 61 (40.4%) | 151 | |
| Sex | ||||
| Male | 101 (61.6%) | 63 (38.4%) | 164 | 0.300 |
| Female | 74 (55.6%) | 59 (44.4%) | 133 | |
| Tumor thickness (mm) | ||||
| <1.0 | 71 (71.7%) | 28 (28.3%) | 99 | 0.0022 |
| 1.0 - <2.0 | 40 (54.8%) | 33 (45.2%) | 73 | |
| 2.0 - 4.0 | 36 (56.25%) | 28 (43.75%) | 64 | |
| >4.0 | 29 (47.5%) | 32 (52.5%) | 61 | |
| Ulceration | ||||
| Present | 30 (56.6%) | 23 (43.4%) | 53 | 0.705 |
| Absent | 145 (59.4%) | 99 (40.6%) | 244 | |
| Tumor subtype | ||||
| Acral Lentiginous | 6 (66.7%) | 3 (33.3%) | 9 | |
| Desmoplastic | 6 (54.5%) | 5 (45.5%) | 11 | |
| Lentigo Maligna | 44 (69.8%) | 19 (30.2%) | 63 | |
| Nodular | 17 (38.6%) | 27 (61.4%) | 44 | 0.0033 |
| Superficial Spreading | 60 (55.0%) | 49 (45.0%) | 109 | |
| Other4 | 43 (70.5%) | 18 (29.5%) | 61 | 0.0455 |
| Location6 | ||||
| Sun-protected | 112 (53.1%) | 99 (46.9%) | 211 | 0.001 |
| Sun-exposed | 61 (73.5%) | 22 (26.5%) | 83 | |
| Metastatic Melanoma (n=148) | ||||
| Age | ||||
| ≤60 | 47 (54.7%) | 39 (45.3%) | 86 | 0.865 |
| >60 | 33 (53.2%) | 29 (46.8%) | 62 | |
| Sex | ||||
| Male | 53 (53.5%) | 46 (46.5%) | 99 | 0.858 |
| Female | 27 (55.1%) | 22 (44.9%) | 49 | |
| AJCC stage | ||||
| I | 110 (64.7%) | 60 (35.3%) | 170 | 0.0157 |
| II | 65 (51.2%) | 62 (48.8%) | 127 | |
| III | 30 (48.4%) | 32 (51.6%) | 62 | |
| IV | 49 (59.0%) | 34 (41.0%) | 83 | |
| Location | ||||
| Cutaneous | 34 (53.1%) | 30 (46.9%) | 64 | 0.2268 |
| Lymph nodal | 27 (49.1%) | 28 (50.9%) | 55 | |
| Visceral | 18 (69.2%) | 8 (30.8%) | 26 | |
AJCC indicates American Joint Committee on Cancer.
1 χ2 test, df = 1 unless otherwise stated.
2 Tumors <1.0mm thick vs. all other tumors.
3 Nodular melanoma vs. all other subtypes.
4 Other: Unspecified subtypes (n=58), spitz-like melanoma (n=1) and nevoid melanoma (n=2).
5 Other melanomas vs. all other subtypes.
6 Sun-protected locations: back, trunk, arms, hands, legs, feet, and vulva; Sun-exposed sites: head and neck. Cases with unspecified location (n=3) were excluded from analysis.
7 AJCC stage I vs. stages II-IV. Samples with unspecified AJCC stages (n=3) were excluded from analysis.
8 Df = 2. Samples lacking information about the location of metastasis (n=3) were excluded from the study