Table 3. Multivariate Cox regression analysis on 5-year overall and disease-specific survival of 271 primary melanoma patients.

Variables1	Overall survival					Disease-specific survival
	β2	SE	HR	95.0% CI	P-value3	β2	SE	HR	95.0% CI	P-value3
Sex	0.034	0.247	1.03	0.64-1.68	0.891	0.028	0.251	1.03	0.63-1.68	0.912
Age	0.380	0.265	1.46	0.87-2.46	0.152	0.447	0.272	1.56	0.92-2.67	0.100
Thickness	0.934	0.420	2.55	1.12-5.80	0.026	1.040	0.449	2.83	1.17-6.82	0.021
Ulceration	1.185	0.262	3.27	1.96-5.47	<0.001	1.212	0.265	3.36	2.00-5.64	<0.001
Location	0.042	0.299	1.04	0.58-1.88	0.889	0.096	0.301	1.10	0.61-1.99	0.749
Cten	0.524	0.253	1.69	1.03-2.77	0.038	0.596	0.258	1.82	1.10-3.01	0.021

¹ Coding of variables: Age was coded as 1 (≤60 years) and 2 (>60 years); sex was coded as 1 (male) and 2 (female); tumor thickness was coded as 1 (<1mm) and 2 (≥1mm); ulceration was coded as 1 (absent) and 2 (present); location was coded as 1 (sun-protected) and 2 (sun-exposed); Cten was coded as 1 (negative-moderate expression) and 2 (strong expression).

² β = regression coefficient.

³ Log-rank test.

Abbreviations: SE, standard error; HR, hazard ratio; CI, confidence interval.