Table 2.
Comparison of TSBA levels and serum bile acid profiles in all of the groups studied.
Normocholanaemic pregnant women (n = 23) | AHP (n = 15) | ICP low pruritus score (n = 9) | ICP high pruritus score (n = 23) | ICP high pruritus score treated with UDCA (n = 23) | |
---|---|---|---|---|---|
TSBA (μM) | 5.8 ± 0.7 | 19.4 ± 2.0§§ | 24.2 ± 8.3 | 54.9 ± 12.2§§ | 47.6 ± 11.9§§ |
UDCA (μM) | 3.1 ± 0.7 | 10.8 ± 1.4§§ | 1.1 ± 0.5 | 5.2 ± 2.8 | 28.3 ± 6.3§§,a |
LCA (μM) | 0.34 ± 0.06 | 0.60 ± 0.28 | 6.5 ± 3.6§ | 20.3 ± 5.6§§ | 2.2 ± 1.0∗,a |
CDCA (μM) | 0.75 ± 0.24 | 1.3 ± 0.7 | 1.8 ± 1.0 | 10.4 ± 4.0∗∗ | 8.8 ± 5.6 |
CA (μM) | 0.40 ± 0.17 | 1.1 ± 0.5 | 8.8 ± 5.2∗∗ | 7.1 ± 2.3§ | 5.7 ± 1.9§ |
DCA (μM) | 1.9 ± 0.6 | 5.6 ± 1.6§ | 6.0 ± 4.3∗ | 12.0 ± 4.6§ | 2.7 ± 1.3§,b |
CA/CDCA | 1.8 ± 0.9 | 5.5 ± 2.7 | 7.7 ± 3.9 | 18.5 ± 10.9 | 13.7 ± 7.5 |
UDCA/LCA ratio | 11.1 ± 2.9 | 41.5 ± 7.5§ | 0.65 ± 0.23§ | 0.59 ± 1.4§§ | 79.9 ± 28.8∗∗,a |
Results are expressed as means ± SEM. Bile acids are expressed in their free, glycine, and taurine forms. ∗ P < 0.05∗∗ P < 0.01, § P < 0.001 and §§ P < 0.0001, with respect to normocholanaemic pregnant women. a P < 0.0001 and b P < 0.05 with respect to ICP high pruritus score.