Table 2.

Comparison of TSBA levels and serum bile acid profiles in all of the groups studied.

	Normocholanaemic pregnant women (n = 23)	AHP (n = 15)	ICP low pruritus score (n = 9)	ICP high pruritus score (n = 23)	ICP high pruritus score treated with UDCA (n = 23)
TSBA (μM)	5.8 ± 0.7	19.4 ± 2.0§§	24.2 ± 8.3	54.9 ± 12.2§§	47.6 ± 11.9§§
UDCA (μM)	3.1 ± 0.7	10.8 ± 1.4§§	1.1 ± 0.5	5.2 ± 2.8	28.3 ± 6.3§§,a
LCA (μM)	0.34 ± 0.06	0.60 ± 0.28	6.5 ± 3.6§	20.3 ± 5.6§§	2.2 ± 1.0∗,a
CDCA (μM)	0.75 ± 0.24	1.3 ± 0.7	1.8 ± 1.0	10.4 ± 4.0∗∗	8.8 ± 5.6
CA (μM)	0.40 ± 0.17	1.1 ± 0.5	8.8 ± 5.2∗∗	7.1 ± 2.3§	5.7 ± 1.9§
DCA (μM)	1.9 ± 0.6	5.6 ± 1.6§	6.0 ± 4.3∗	12.0 ± 4.6§	2.7 ± 1.3§,b
CA/CDCA	1.8 ± 0.9	5.5 ± 2.7	7.7 ± 3.9	18.5 ± 10.9	13.7 ± 7.5
UDCA/LCA ratio	11.1 ± 2.9	41.5 ± 7.5§	0.65 ± 0.23§	0.59 ± 1.4§§	79.9 ± 28.8∗∗,a

Results are expressed as means ± SEM. Bile acids are expressed in their free, glycine, and taurine forms. ^∗ P < 0.05^∗∗ P < 0.01, ^§ P < 0.001 and ^§§ P < 0.0001, with respect to normocholanaemic pregnant women. ^a P < 0.0001 and ^b P < 0.05 with respect to ICP high pruritus score.