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. 2013 Nov 7;8(11):e80260. doi: 10.1371/journal.pone.0080260

Figure 1. Gene expression profiles of cytokines and chemokines in the brain after HI and TBI.

Figure 1

A) Overview of the experimental protocol. HI, TBI and Tx denote focal head irradiation, total body irradiation and bone marrow transplantation, respectively. B) Quantitative real-time PCR of CCL2, CXCL10, CCL5 and TNF-α mRNA expression in brains of HI (grey columns) and TBI (white columns) animals at 1, 2, 4 and 16 weeks after irradiation and BMT. The mRNA expression levels were normalized to GAPDH mRNA and compared to naïve mice (fold induction). Reduced cytokine/chemokine mRNA levels were observed in HI brains compared to the TBI paradigm. Data are means + SEM from 3-5 animals per group. Statistical significance is indicated by asterisks (*p<0.05; **p<0.01; ***p<0.001).