Table 2. Mean percentage of proliferation of healthy donor peripheral blood mononuclear cells (PBMCs) stimulated with PHA in the presence of HD-MSCs, as compared with ALL-MSCs generated at day+0; +15; +33; +78 at two different MSC∶PBMC ratios (1∶2; 1∶10).
PBMC proliferation | P value | PBMC proliferation | P value | |
Ratio 1∶2 | Ratio 1∶10 | |||
HD-MSCs | 6.19 (SD ±2.55) | - | 31.71 (SD ±13.49) | - |
ALL-MSCs d+0 | 9.85 (SD ±3.50) | 0.38 | 42.24 (SD ±17.93) | 0.31 |
ALL-MSCs d+15 | 8.64 (SD ±4.82) | 0.42 | 34.07 (SD ±14.50) | 0.46 |
ALL-MSCs d+33 | 10.66 (SD ±6.12) | 0.36 | 40.85 (SD ±15.23) | 0.34 |
ALL-MSCs d+78 | 11.84 (SD ±5.12) | 0.33 | 36.61 (SD ±14.58) | 0.41 |
Each value represents the mean ± SD of multiple experiments (each point being in triplicate). PBMC proliferation stimulated with PHA in the absence of MSCs was 71.80%. P values less than 0.05 were considered to be statistically significant.