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. 2013 Nov 7;8(11):e78179. doi: 10.1371/journal.pone.0078179

Figure 1. Upon keratinocyte differentiation RNAP binding and mRNA levels are preferentially induced when promoters are bound by combinations of C/EBPβ and cJun.

Figure 1

A. Scatterplott of changes in RNAP binding after differentiation versus RNAP binding in undifferentiated keratinocytes show 797 and 841 promoters are induced or repressed upon differentiation. These changes correlate with changes in mRNA levels. B. Transcription factors CREB, C/EBPβ and c-Jun bind distinct set of promoters in differentiated keratinocytes. Euler diagrams show that promoters bound by C/EBPβ and c-Jun are preferentially induced by differentiation and promoters bond by CREB are not. C. Fraction of promoters bound by different combination of transcription factors in differentiated keratinocytes where RNAP binding is repressed (white bars) or induced by differentiation (black bars). D. Fraction of genes with mRNA levels induced or repressed by differentiation more than 1.4 times in groups of promoters bound by different combinations of transcription factors. * - values are different from expected (p<0.005 using a two-tailed unpaired t-test).