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. 2013 Sep 2;6(5):1251–1258. doi: 10.3892/etm.2013.1284

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Copyright © 2013, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Figure 1. — Airway (A) inspiratory and (B) expiratory resistance in response to varied doses of MCH in the four groups were analyzed using an animal lung function apparatus. Dose-response curves showed that the airway response to MCH was significantly increased in the OVA and NGF groups compared with that of the control group (P<0.01). Treatment of OVA-sensitized rats with anti-NGF prevented this increase in airway reactivity (P<0.01). ▪P<0.01 compared with the control group, ^▴P<0.01 and ^▴▴P<0.05 compared with the OVA group. MCH, methacholine; OVA, ovalbumin; NGF, nerve growth factor; IR, inspiratory resistance; ER, expiratory resistance.