Table III.

Pharmacokinetic parameters of ferulic acid in serum following the oral administration of Guanxin II.

Parameter	Angina pectoris patients (n=18)	Healthy volunteers (n=18)
Tmax (min)	23.95±7.96	30.00±0.00
Cmax (ng/ml)	26.20±4.45	33.50±3.83a
AUC0–240 (μg/ml/min)	2.72±0.83	3.56±0.70
t1/2α (min)	15.02±3.62	20.77±3.58a
t1/2β (min)	106.23±40.72	772.36±199.04b
t1/2Ka (min)	9.89±4.23	15.20±3.12a

^aP<0.05,

^bP<0.01 compared with the patients with angina pectoris. T_max, time to maximum serum concentration; C_max, maximum serum concentration; AUC_0–240, area under the curve in 0–240 min; t_1/2α, distribution half life; t_1/2β, elimination half life; t_1/2Ka, absorption half life.