Table 3. Muscular lesions at the site of injection in rabbit toxicological study, 2 days after the last immunization.
| Group | Treatment | Dose of EV71 (µg) | Muscle Degeneration (animals/group) | ||
| Without Infiltration | With Infiltration | Totala | |||
| G1 | Saline Placebo | 0 | 0/12 | 0/12 | 0/12 |
| G2 | Alhydrogel Placebob | 0 | 4/16 | 2/16 | 6/16 |
| G3 | Vaccine Low Dose | 0.6 | 4/20 | 6/20 | 10/20 |
| G4 | Vaccine High Dose | 3.0 | 0/20 | 8/20 | 8/20 |
a
Values shown under total are the total number of observations of muscle degeneration with and without MNC/eosinophil infiltration.
b
The Alhydrogel Placebo group received an Alhydrogel-only adjuvant formulation.