Table III.
The 16 proteins that were identified using iTRAQ as having ≥1.5-fold differences in their expression level between patients with HBV-induced ACLF and CHB, respectively, and healthy controls.
| Accession no. | Protein name | Biological processes | Molecular function | Protein function | Levels in patients with CHB versus controls | Levels in HBV-induced ACLF patients versus controls |
|---|---|---|---|---|---|---|
| Q7TMA5 | Apolipoprotein B-100 precursor | Cholesterol and lipid metabolism, lipid transport | Heparin binding | Transporter | Upregulated 1.62-fold | Upregulated 1.32-fold |
| P04004 | Vitronectin | Cell adhesion | Heparin and integrin binding | Cell adhesion molecule | Downregulated 1.23-fold | Downregulated 2.14-fold |
| P01764 | Monoclonal IgM antibody heavy chain | Immune response | Antigen binding | Defense/immunity protein | Upregulated 1.41-fold | Upregulated 1.87-fold |
| Unclassified | Unnamed protein product | Unclassified | Unclassified | Unclassified | Downregulated 1.23-fold | Downregulated 2.14-fold |
| P02768 | Serum albumin preproprotein | Transport | Binding capacity | Transporter | Upregulated 1.86-fold | Upregulated 2.83-fold |
| Unclassified | Apolipoprotein J precursor | Unclassified | Unclassified | Unclassified | Downregulated 1.23-fold | Downregulated 2.00-fold |
| Unclassified | Unnamed protein product | Unclassified | Unclassified | Unclassified | Upregulated 1.07-fold | Upregulated 2.00-fold |
| D3DUX1 | Serpin peptidase inhibitor, clade A | Regulatory | Serine-type endopeptidase inhibitor activity | Regulatory molecular | Normal | Upregulated 2.64-fold |
| P00450 | Ceruloplasmin (ferroxidase), isoform CRA_b | Copper and iron transport | Chaperone binding, ferroxidase activity | Transporter | Upregulated 2.30-fold | Upregulated 2.64-fold |
| P07203 | Glutathione peroxidase | UV protection, anti apoptosis, cell redox homeostasis and glutathione metabolic process | Oxidoreductase, peroxidase | Regulatory molecular | Downregulated 1.07-fold | Upregulated 2.46-fold |
| P68871 | Hemoglobin β chain variant Hb S-Wake | Oxygen transport | Hypotensive agent, vasoactive | Transporter | Downregulated 1.07-fold | Upregulated 9.19-fold |
| B3KUE5 | Phospholipid transfer protein, isoform CRA_c | Regulatory | Lipid binding | Regulatory molecular | Upregulated 1.32-fold | Upregulated 4.92-fold |
| Unclassified | Platelet factor 4 precursor | Unclassified | Unclassified | Unclassified | Downregulated 1.15-fold | Downregulated 1.87-fold |
| P19095 | C reactive protein precursor | Acute phase response | Sugar binding | Unclassified | Downregulated 2.46-fold | Upregulated 4.59-fold |
| P18428 | Lipopolysaccharide binding protein, isoform CRA_a | Lipid transport, transport | Antibiotic, antimicrobial | Transporter | Upregulated 1.07-fold | Upregulated 1.62-fold |
| P60709 | Actin, β | Cellular component movement | ATP and kinesin binding | Extracellular matrix | Downregulated 1.23-fold | Upregulated 4.29-fold |
iTRAQ, isobaric tags for relative and absolute quantitation; HBV, hepatitis B virus; ACLF, acute-on-chronic liver failure; CHB, chronic hepatitis B; IgM, immunoglobulin M.