Table 2. Effect of replication direction relative to transcription on mutation rates.

		Mutation rate (×10−10)
lys2 allele	Relevant	2- or-4 bp deletions		QP mutations
	genotype	SAME	OPPO	SAME	OPPO
lys2ΔBgl	WT	10.2	9.7	<10*	<9.7*
	rnh201Δ	1160	1500	865	<29*
	rnh201Δ top1Δ	<23*	<19*	631	<19**
lys2ΔA746	WT	62.2	54.1	<3.7*	<3.6*
	rnh201Δ	1220	689	499	48
	rnh201Δ top1Δ	<16.3*	7.8	326	31
lys2ΔA746,NR	WT	<1.9*	<1.6*	<1.9*	<1.6*
	rnh201Δ	796	394	337	<12*
	rnh201Δ top1Δ	<18*	<8.9*	338	36

All rates were measured under high-transcription conditions. Total Lys⁺ rates and the associated 95% confidence intervals are provided in Supplemental Tables.

^*No events were observed; rate calculated assuming one event.