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Ifitm3 is a type II transmembrane protein. Ifitm3 contains an N-terminal intramembrane domain (IM1) and C-terminal transmembrane domain (TM2) flanking the conserved intracellular loop (CIL) with an extracellular C terminus and intracellular N terminus. Lines of evidence from this study supporting a type II topology are listed next to the N and C termini of the molecule.
