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Average inhibitory activities of TWEAK binding to Fn14. A, average inhibitory activities for compounds that demonstrated ≥15% reduction in Fn14-TWEAK binding in the ELISA during the first round of screening (4 of 60 compounds). B, average inhibitory activities for compounds that demonstrated ≥15% reduction in Fn14-TWEAK binding in the ELISA during the follow-up round of screening (15 of 69 compounds).
