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L524-0366 specifically inhibits TWEAK-Fn14-mediated NF-κB activation. A, NF-kB Luc reporter cells treated with TNFα or Fn14-NF-kB-Luc reporter cells treated with TWEAK were incubated with vehicle (VC) or L524-0366. NF-κB-driven luminescent signal was determined using Bright-Glo assay. B, dose-response curve of inhibitory activity of L524-0366 in Fn14-NF-κB-Luc and NF-κB-Luc cells following TWEAK and TNFα stimulation, respectively. RLU, relative luminescence units.
