FIGURE 2.

Homology modeling of TWEAK. A, consensus structural alignment performed in MOE (Chemical Computing Group) for six members of TNF superfamily. B, TWEAK sequence (black) aligned to the consensus structure-derived sequence alignment of the six template TNF ligands. The sequence alignment of the six template ligands, identified by their PDB code and color-coded based on the chain color in A, was derived from the structure alignment. The TWEAK sequence was aligned onto the multiple alignment of the six templates.