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Prioritized binding models for Fn14-TWEAK. A and B, three-dimensional representations of the two TWEAK-Fn14 prioritized models with TWEAK Tyr176 serving as an anchor residue to bind Fn14 CRD. C and D, three-dimensional representations of the two prioritized models with TWEAK Trp231 serving as an anchor to bind Fn14 CRD. A van der Waals surface is overlaid on the Fn14 CRD in all panels.
