TABLE 2.

Species-specific differences in α₄ β-propeller blades 2–4

Residues in the natalizumab epitope are in bold.

Region	Residue	Human	Mouse
W2, β2-β3	121	Ile	Met
W2, β2-β3	123	Asn	Ser
W2, β2-β3	124	Glu	Asp
W2, β3	131	Gly	Ile
W2, β3	134	Gly	Val
W2, β3	135	Val	Met
W2, β3-β4	137	Pro	Ser
W2, β4	147	Ile	Met
W3, β4-β1	152	Gln	Lys
W3, β4-β1	155	Val	Thr
W3, β1-β2	175	Lys	Gln
W3, β3-β4	201	Lys	Gln
W4, β4-β1	208	Lys	Arg
W4, β1-β2	230	Gln	Pro
W4, β3-β4	256	Lys	Asn