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Structures of Rab8 in its inactive GDP-bound and active GppNHp-bound forms. A, structure of Rab8·GDP. B, structure of Rab8·GppNHp. C, structural comparison of Rab8 in its inactive and active states. Superposition indicates that in its inactive GDP-bound form, the switch domains adopt unfolded conformations or ordered conformations that depend on crystal packing. Conversely, in its active GppNHp-bound form, the switch domains adopt well defined conformations.
