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Schematic depiction of Rabin8 and GRAB. A, domain architecture of Rabin8 and GRAB. The GEF activity is confined to the Sec2 homology domain. Rabin8 contains a Rab11-binding domain (RBD) (10). B, sequence alignment of GRAB, Rabin8, and Sec2 in the GEF domain. Identical amino acids are shown in purple.
