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Ser-175 phosphorylation tunes kinesin transport. A, phosphorylation (red circle) stabilizes the autoinhibition of kinesin (blue) and decreases its stall force. Phosphorylated kinesin loses a tug-of-war against dynein (purple), leading to an increase in minus-end directed transport. B, unphosphorylated kinesin can exert higher forces, leading to more plus-end-directed transport, and is less strongly autoinhibited than Ser-175-phosphorylated kinesin.
