Table III. Macaque sperm proteins with mammalian sperm phenotypes.
| Phenotype | Mammalian phenotype IDa | Total genes in genome | Genes identified in the MacSP |
|---|---|---|---|
| Abnormal morphology | |||
| Axoneme | 9838 | 13 | ODF2, SPAG6, THEG, TEKT2, VDAC3 |
| Flagellumb | 8892, 8545, 9238, 8893, 9243, 9237, 9839, 9239 | 104 | AKAP4, ATP1A4, CSNK2A1, CSNK2A2, HK1, OAZ3, ODF2, PPP1CC, PRSS21, SPAG6, TCTE3, TEKT2, TEKT3, TEKT4, THEG, ZPBP, ZPBP2 |
| Head | 9230 | 122 | ACR, CSNK2A1, CSNK2A2, CD59, H1FNT, PPP1CC, PRSS21, SMCP, TCTE3, TSSK4, SPAG6 |
| Nucleus | 9232 | 26 | CSNK2A1, CSNK2A2, GPX5, H1FNT, HK1, THEG, ZPBP, ZPBP2 |
| Principle piece | 9836 | 8 | AKAP4, PPP1CC, SPAG6, TEKT4 |
| Midpiece | 9831 | 27 | NUP210L, ODF2, PPP1CC, TEKT4, SPAG6 |
| Mitochondrial sheath | 9832, 9833 | 19 | AKAP4, PPP1CC, VDAC3 |
| Spermatogonia | 6378 | 32 | ALPL |
| Spermatid | 6380 | 125 | ATM, CSNK2A1, CSNK2A2, CSTF2T, HERC2, HK1, NPEPPS, PPP1CC, PRKDC, PSME4, RSPH1, THEG, TSSK2, ZPBP, ZPBP2 |
| Spermatocyte | 6379 | 59 | ATM, DDX4, PLEKHA1, PSME4, SLC25A31 |
| Abnormal Process | |||
| Spermatogenesis | 1156, 8261 | 386 | ALMS1, BSG, GNPAT, H1FNT, HRG, HSP90AA1, HSPA4L, IMMP2L, KLHL10, LMNA, MLH3, NR2C2, RET, RPS27A, STX2, SUV39H1, TDRD6 |
| Physiology | 4543 | 215 | AQP7, ATP1A4, ATP2B4, CRISP1, KCNU1, LDHC, PPP1CC, PRSS21, RSPH1, SPAM1, SPESP1, TEKT4, ZAN |
| Capacitation | 3666 | 36 | ADCY3, ATP1A4, KCNU1 |
| Motility | 2674, 2675 | 187 | ADAM2, CAPZA3, CHDH, CSNK2A1, CSNK2A2, DNAH1, GAPDHS, HSPA4L, PGK2, PRKACA, TEKT2 |
| Fertilization | 242, 5410, 5411 | 96 | ACR, ACRBP, ADAM1, ADCY3, ATP1A4, CD46, IZUMO1, KCNU1, LDHC, PRKACA, PRSS21, SERPINA5, SMCP, SPAM1, SPESP1, ZPBP2 |
a Mammalian phenotypes were obtained from the Mouse Genome Informatics database.
b Defects include abnormal flagellum morphology (coiled, detached, hairpin, kinked, and short), flagellum absence and multiflagellate sperm.