Table I. Top 50 phospholipid-associated protein pairings as determined by composite correlation score (from 2701 scored pairs ranging from 2.87 to −1.47).
Rank | Protein A | Protein B | Correlation score |
|||
---|---|---|---|---|---|---|
Gel filtration | Anion exchange | IEF | Comp.a | |||
1 | Fibrinogen β chain | Fibrinogen γ chain | 0.95 | 0.97 | 0.95 | 2.87 |
2 | Fibrinogen α chain | Fibrinogen β chain | 0.98 | 0.98 | 0.90 | 2.86 |
3 | ApoA-I | ApoA-II | 0.96 | 0.94 | 0.95 | 2.85 |
4 | Fibrinogen α chain | Fibrinogen γ chain | 0.94 | 0.97 | 0.92 | 2.83 |
5 | IgG h. chain V-III region BRO | IgG κ chain C region | 0.92 | 0.91 | 0.90 | 2.73 |
6 | Complement factor B | Histidine-rich glycoprotein | 0.91 | 0.95 | 0.81 | 2.67 |
7 | ApoA-IV | Kallistatin | 0.79 | 0.94 | 0.93 | 2.67 |
8 | IgGγ-1 chain C region | IgG κ chain C region | 0.94 | 0.77 | 0.92 | 2.62 |
9 | Complement C8 α | Complement C8 β | 0.99 | 0.88 | 0.74 | 2.61 |
10 | Insulin-like growth factor-binding protein 1 | Inter-α-trypsin inhibitor 4 | 0.87 | 0.99 | 0.76 | 2.61 |
11 | Insulin-like growth factor-binding protein 1 | Extracellular matrix protein 1 | 0.79 | 0.89 | 0.92 | 2.59 |
12 | IgG κ chain C region | IgG λ-1 chain C region | 0.97 | 0.87 | 0.74 | 2.58 |
13 | Complement factor I | Hemopexin | 0.92 | 0.92 | 0.73 | 2.56 |
14 | Inter-α-trypsin inhibitor 1 | Inter-α-trypsin inhibitor 2 | 0.94 | 0.99 | 0.59 | 2.51 |
15 | Complement factor B | n-acetylmuramoyl-l-ala. amid. | 0.95 | 0.96 | 0.59 | 2.50 |
16 | IgG γ-1 chain C region | IgG λ-1 chain C region | 0.91 | 0.75 | 0.84 | 2.50 |
17 | IgG heavy chain V-III reg. BRO | IgG γ-1 chain C region | 0.82 | 0.83 | 0.79 | 2.44 |
18 | Complement factor C4-B | Complement C5 | 0.65 | 0.84 | 0.93 | 2.43 |
19 | IgG κ chain C region | IgG λ chain V-I region HA | 0.87 | 0.76 | 0.80 | 2.43 |
20 | IgG heavy chain V-III reg. BRO | IgG λ-1 chain C region | 0.89 | 0.80 | 0.72 | 2.41 |
21 | IgG γ-1 chain C region | IgG λ chain V-I region HA | 0.84 | 0.86 | 0.70 | 2.41 |
22 | IgG heavy chain V-III reg. BRO | IgG λ chain V-I region HA | 0.85 | 0.76 | 0.76 | 2.37 |
23 | Complement C1s | Complement factor C4-B | 0.95 | 0.49 | 0.92 | 2.35 |
24 | α-1-antichymotrypsin | ApoJ | 0.87 | 0.58 | 0.87 | 2.32 |
25 | Complement factor B | Coagulation factor XII | 0.85 | 0.93 | 0.51 | 2.29 |
26 | Carboxypeptidase B2 | Kallistatin | 0.83 | 0.92 | 0.53 | 2.27 |
27 | Extracellular matrix protein 1 | Inter-α-trypsin inhibitor 4 | 0.71 | 0.91 | 0.65 | 2.27 |
28 | Histidine-rich glycoprotein | n-acetylmuramoyl-l-ala. amid. | 0.91 | 0.93 | 0.40 | 2.25 |
29 | IgG λ-1 chain C region | Ig λ chain V-I region HA | 0.79 | 0.78 | 0.65 | 2.21 |
30 | Antithrombin-III | Pigment epithelial-derived factor | 1.00 | 0.85 | 0.34 | 2.18 |
31 | α-1-antichymotrypsin | Kininogen-1 | 0.90 | 0.40 | 0.88 | 2.18 |
32 | ApoA-II | Extracellular matrix protein 1 | 0.48 | 0.83 | 0.87 | 2.18 |
33 | α-1B-glycoprotein | α-2-HS-glycoprotein | 0.84 | 0.50 | 0.82 | 2.16 |
34 | ApoH | Plasminogen | 0.83 | 0.90 | 0.42 | 2.15 |
35 | ApoA-I | Extracellular matrix protein 1 | 0.51 | 0.78 | 0.84 | 2.13 |
36 | Complement C9 | Heparin cofactor 2 | 0.39 | 0.80 | 0.91 | 2.09 |
37 | ApoJ | Inter-α-trypsin inhibitor 4 | 0.84 | 0.71 | 0.55 | 2.09 |
38 | ApoA-I | ApoM | 0.73 | 0.53 | 0.82 | 2.08 |
39 | Complement C1s | Complement C5 | 0.44 | 0.74 | 0.90 | 2.08 |
40 | α-1B-glycoprotein | Coagulation factor XII | 0.44 | 0.99 | 0.64 | 2.07 |
41 | Antithrombin-III | ApoA-IV | 0.30 | 0.92 | 0.83 | 2.05 |
42 | ApoA-II | ApoM | 0.72 | 0.44 | 0.87 | 2.04 |
43 | ApoC-I | Complement C7 | 0.67 | 0.64 | 0.72 | 2.03 |
44 | Complement factor B | Hemopexin | 0.45 | 0.92 | 0.64 | 2.01 |
45 | α-1B-glycoprotein | n-acetylmuramoyl-l-ala. amid. | 0.90 | 0.89 | 0.21 | 2.01 |
46 | α-2-macroglobulin | Ig μ chain C region | 0.72 | 0.57 | 0.70 | 1.99 |
47 | Coagulation factor XII | Histidine-rich glycoprotein | 0.66 | 0.84 | 0.48 | 1.98 |
48 | Plasminogen | Serotransferrin | 0.98 | 0.73 | 0.27 | 1.98 |
49 | ApoJ | Haptoglobin | 0.77 | 0.28 | 0.93 | 1.98 |
50 | ApoA-IV | Carboxypeptidase B2 | 0.46 | 0.88 | 0.63 | 1.97 |
79 | ApoL-I | Haptoglobin-related protein | 0.72 | 0.70 | 0.39 | 1.81 |
a Composite score (i.e. sum of individual separation correlation scores).