Table II. Prioritized co-GCM genes represented by SNPs in evolutionarily conserved regions for further genotyping in Malmö Diet and Cancer Cardiovascular cohort (MDC-CC) cohort.
| Trait | Gene | SNP | GLGC p-vlaue | Variant type/location | DAPPLE | Genewanderer ranking | GRAIL p value |
|---|---|---|---|---|---|---|---|
| HDL-C | INSR | rs8101064 | 2.03E-05 | INTRONIC | ✓ | 1 | 0.9 |
| ASCC2 | rs140147 | 0.0006 | SPLICE_SITE | 3 | 0.99 | ||
| CYP3A4 | rs12721617 | 0.002 | INTRONIC | 1 | 0.031 | ||
| APP | rs380713 | 0.003 | INTERGENIC | 1 | 0.3 | ||
| SMURF2 | rs6504248 | 0.006 | INTERGENIC | 1 | 0.96 | ||
| EHMT2 | rs9267659 | 0.008 | INTRONIC | 7 | 4.92E-11 | ||
| SKIL | rs6763533 | 0.009 | INTRONIC | 1 | 0.96 | ||
| PSMA1 | rs12362721 | 0.02 | INTRONIC | 3 | 0.126 | ||
| TERT | rs6554691 | 0.02 | INTRONIC | 1 | 0.636 | ||
| RALYL | rs6473532 | 0.03 | INTERGENIC | NA | 0.956 | ||
| FASN | rs6502051 | 0.04 | INTRONIC | 1 | 0.45 | ||
| LDL-C | NDUFA4L2 | rs11172134 | 0.0003 | UPSTREAM | ✓ | NA | 0.0006 |
| CDK5RAP2 | rs3739822 | 0.0008 | SYNONYMOUS_CODING | ✓ | 5 | 0.65 | |
| ITGB3BP | rs6588048 | 0.003 | INTRONIC | 3 | 0.98 | ||
| SH3GL3 | rs8025427 | 0.03 | INTRONIC | 1 | 0.48 | ||
| TC | CBS | rs234706 | 0.007 | SYNONYMOUS_CODING | 2 | 0.13 | |
| ASAP1 | rs7462286 | 0.02 | INTRONIC | ✓ | 1 | 0.42 | |
| ITSN1 | rs9984662 | 0.03 | 3PRIME_UTR | 13 | NA | ||
| EXOSC10 | rs11583740 | 0.03 | INTRONIC | 5 | 0.75 | ||
| TG | DNM2 | rs3826803 | 0.003 | INTRONIC | 5 | 0.85 | |
| HNF4A | rs3212198 | 0.003 | INTRONIC | 1 | 0.22 | ||
| PAFAH1B3 | rs3826706 | 0.02 | INTRONIC | ✓ | 5 | 0.7 | |
| COPS6 | rs2307345 | 0.02 | INTRONIC | 5 | 0.43 | ||
| ATP6V1E1 | rs3532 | 0.02 | 3PRIME_UTR | 3 | 0.86 | ||
| NR2F2 | rs4310804 | 0.04 | INTERGENIC | 2 | NA |