Table IV. Association of selected GCM gene SNPs with their respective traits in MDC-CC. A synonmyous SNP (rs234706) in CBS gene was significantly associated with the TC trait in MDC-CC.
| Trait | N | SNP (Chr) | Gene | Minor Allele (frequency, %) | Beta (S.E.) | p value |
|---|---|---|---|---|---|---|
| HDL-C | 4916 | rs8101064 (19) | INSR | T (3.9) | −0.001 (0.001) | 0.50 |
| LDL-C | 4822 | rs11172134 (12) | NDUFA4L2 | A (23.7) | 0.003 (0.02) | 0.91 |
| TC | 4962 | rs234706 (21) | CBS | A (45.9) | 0.06 (0.02) | 0.0032 |
| TG | 4933 | rs3826803 (19) | DNM2 | C (35.0) | 0.004 (0.01) | 0.68 |