Figure 4.

Copy of Figure 3B annotated for amino acid usage bias. The coloring for the labels signifies whether that position is hydrophobic (red), weak hydrophobic (light red), neutral (purple), weak hydrophilic (light blue), hydrophilic (blue), or indeterminate (black), while a circle around the position indicates that the position shares the same hydrophobicity bias as the equivalent germline position. All amino acids are changed.