Table 2.
Incidence of SPTs by Treatment Arm (252 SPTs observed in 224 patients)
| Site of SPT | Placebo |
Selenium |
||
|---|---|---|---|---|
| No. | % | No. | % | |
| Breast | 2 | 2.4 | 8 | 4.7 |
| Colon | 3 | 3.6 | 3 | 1.8 |
| Rectum | 1 | 1.2 | 1 | 0.6 |
| Gastric | 0 | 0.0 | 1 | 0.6 |
| Pancreas | 3 | 3.6 | 5 | 3.0 |
| Esophagus | 0 | 0.0 | 1 | 0.6 |
| Liver, gallbladder, bile duct | 0 | 0.0 | 6 | 3.6 |
| Small Intestines | 0 | 0.0 | 1 | 0.6 |
| Head and neck | 2 | 2.4 | 4 | 2.4 |
| Thyroid | 2 | 2.4 | 2 | 1.2 |
| Myeloma | 0 | 0.0 | 2 | 1.2 |
| Chronic lymphocytic leukemia | 1 | 1.2 | 1 | 0.6 |
| Acute non–lymphocytic leukemia, AML | 1 | 1.2 | 0 | 0.0 |
| Chronic myelogenous leukemia | 0 | 0.0 | 1 | 0.6 |
| Myelodysplastic syndrome | 1 | 1.2 | 4 | 2.4 |
| Lung cancer | 23 | 28.1 | 58 | 34.1 |
| Small-cell lung | 3 | 3.6 | 3 | 1.8 |
| Non–small-cell lung | 2 | 2.4 | 9 | 5.4 |
| Melanoma | 2 | 2.4 | 5 | 3.0 |
| Basal cell carcinoma | 13 | 15.9 | 14 | 8.3 |
| Skin cancer not melanoma | 6 | 7.2 | 11 | 6.6 |
| Kaposi's sarcoma | 1 | 1.2 | 0 | 0.0 |
| Bladder, urinary tract | 6 | 7.3 | 9 | 5.2 |
| Prostate | 9 | 11.0 | 16 | 9.5 |
| Cervix | 0 | 0.0 | 1 | 0.6 |
| Chest wall | 0 | 0.0 | 1 | 0.6 |
| Vocal cord | 1 | 1.2 | 0 | 0.0 |
| Inguen (groin) | 0 | 0.0 | 1 | 0.6 |
| Left groin lymph node | 0 | 0.0 | 1 | 0.6 |
| Unknown | 1 | 1.2 | 0 | 0.0 |
| Total | 83 | 169 | ||
Abbreviations: AML, acute myeloid leukemia; SPT, second primary tumor.