Table 4. Hemodynamic parameters in the left ventricle and in the aorta on day 28 after myocardial infarction in comparison with reference values in sham C57BL/6 LDLr−/− mice.
Sham (n=19) | Control MI (n=11) | AdA-I MI (n=11) | |
---|---|---|---|
Left ventricle | |||
Peak systolic pressure (mm Hg) | 103±2 | 84.9±2.6§§§ | 95.9±3.8* |
End-diastolic pressure (mm Hg) | 2.19±0.68 | 4.81±1.75 | 1.92±0.92 |
Peak dP/dt max (mm Hg ms−1) | 12.1±0.6 | 6.60±0.27§§§ | 9.01±0.54§§** |
Peak dP/dt min (mm Hg ms−1) | −8.7±0.38 | −5.57±0.23§§§ | −7.32±0.48§** |
Tau (ms) | 5.19±0.29 | 6.90±0.35§§ | 5.75±0.31* |
Heart rate (bpm) | 601±15 | 554±23 | 573±26 |
Aorta | |||
Mean pressure (mm Hg) | 78.8±2.1 | 64.3±2.6§§ | 78.4±4.2** |
Peak systolic pressure (mm Hg) | 99.5±2.0 | 81.0±2.3§§§ | 96.1±4.4** |
Peak diastolic pressure (mm Hg) | 60.2±2.7 | 50.6±3.3 | 63.2±3.5* |
Abbreviations: LDLr, low-density lipoprotein receptor; MI, myocardial infarction.
Data are expressed as means±s.e.m. *P<0.05; **P<0.01 for comparison versus control MI. §P<0.05; §§P<0.01; §§§P<0.001 versus Sham.