Table 5. Comparison of infarct parameters and of left ventricular remodelling at day 28 after myocardial infarction in mice without and with prior irradiation and bone marrow transplantation.
|
No prior bone marrow transplantation |
Prior bone marrow transplantation |
|||
|---|---|---|---|---|
| Control MI (n=16) | AdA-I MI (n=16) | Control MI (n=16) | AdA-I MI (n=14) | |
| Infarct area (mm2) | 3.06±0.16 | 2.84±0.26 | 2.44±0.17§ | 2.05±0.17§ |
| Infarct length (μm) | 9750±580 | 7430±800* | 5000±280§§§§ | 4220±250§§* |
| Infarct thickness (μm) | 270±12 | 379±25*** | 590±24§§§§ | 613±17§§§§ |
| Whole left ventricular area (mm2) | 26.3±1.5 | 23.0±0.9 | 19.2±0.5§§§ | 17.5±0.5§§§§* |
| Left ventricular cavity area (mm2) | 16.2±1.5 | 11.7±1.3* | 7.30±0.58§§§§ | 5.98±0.40§§§ |
| Left ventricular muscle area (mm2) | 7.08±0.60 | 8.49±0.65 | 9.44±0.36§§ | 9.46±0.32 |
| Septal wall thickness (μm) | 1060±30 | 1240±60 | 1100±30 | 1150±40 |
| Cardiomyocyte cross-sectional area (μm2) | 405±16 | 399±17 | 293±12§§§§ | 282±12§§§§ |
| Capillary density (number mm−2) | 4140±270 | 4620±290 | 3380±180§ | 3550±170§§ |
Abbreviation: MI, myocardial infarction.
Data are expressed as means±s.e.m. *P<0.05; ***P<0.001 for control MI versus AdA-I MI. §P<0.05; §§P<0.01; §§§P<0.001; §§§§P<0.0001 for prior bone marrow transplantation groups versus respective no prior bone marrow transplantation groups.