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. 2013 Aug 30;51(3):301–312. doi: 10.1530/JME-13-0169

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© 2013 Society for Endocrinology

This work is licensed under a Creative Commons Attribution 3.0 Unported License

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Nucleotide sequences of the region flanking the GNMT ARE in multiple species are shown. The box demarks the region of ARE homology and the translation start site is underlined. Sequences were retrieved from the UCSC (http://genome.ucsc.edu) using the following genome builds: hg19 (human), mm10 (mouse), rn5 (rat), oryCun2 (rabbit), anoCar2 (lizard), xenTro3 (xenopus) and danRer7 (zebrafish). Multiple-sequence alignment was performed using Clustal Omega (http://www.ebi.ac.uk/Tools/msa/clustalo/). Any nucleotide change from the human sequence is in bold and underlined. ‘*’ indicates positions that have a single, fully conserved residue; ’.’ indicates conservation between groups of weakly similar properties (scoring≤0.5 in the Gonnet PAM 250 matrix).