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. Author manuscript; available in PMC: 2014 Aug 15.
Published in final edited form as: Bioorg Med Chem. 2013 Apr 18;21(16):10.1016/j.bmc.2013.04.020. doi: 10.1016/j.bmc.2013.04.020

Table 1.

MIC values of two structural classes of small molecules that kill an OM-permeabilized strain of E. coli

graphic file with name nihms480451u1.jpg
Compound R R′ Amine MIC (μM)
References
Wild typea Leakya
1a H 6-Cl — >100 25 29
1b H 2-Cl, 6-Cl — >100 12.5 30
1c H 2-Br — >100 12.5 30
1d H 2-SMe — >100 25 30
2a Me O(CH2)3 NMe2 >100 25 31
2b Me O(CH2)3 Npyrrol >100 100 31
2c (CH2)2OH O(CH2)3 Npyrrol >100 100 31
2d Me SO2(CH2)3 Npyrrol >100 50 31
a

Wild type cells are E. coli strain MC4100; leaky cells are E. coli strain NR698.32