Table 3. Relapse-Free Survival (RFS) and Overall Survival (OS) by total cMET and phospho-cMET levels and breast cancer subtype.
Relapse-Free Survival (RFS) | Overall Survival (OS) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Tumor Subtypes | Protein Level | Patients | Events | 5-year RFS (%) |
95% CI | P | Events | 5-year OS (%) |
95% CI | P | |
Overall | cMET | High | 181 | 63 | 61.3 | 53.2-70.7 | 0.003 | 43 | 72.4 | 64.7-81.0 | 0.003 |
Low | 76 | 13 | 78.9 | 68.6-90.8 | 7 | 93.3 | 87.8-99.2 | ||||
p-cMET | High | 123 | 45 | 58.9 | 49.1-70.7 | 0.033 | 32 | 72.4 | 63.7-82.3 | 0.025 | |
Low | 134 | 31 | 73.8 | 65.6-83.1 | 18 | 85.8 | 79.4-92.7 | ||||
Hormone receptor-positive |
cMET | High | 103 | 31 | 65.4 | 54.7-78.2 | 0.014 | 17 | 82.8 | 75.0-91.3 | 0.006 |
Low | 37 | 4 | 85.3 | 78.2-100 | 1 | 100 | NA-NA | ||||
p-cMET | High | 75 | 21 | 67.6 | 55.6-82.2 | 0.519 | 11 | 85.2 | 77.0-94.2 | 0.519 | |
Low | 65 | 14 | 75.1 | 63.3-89.2 | 7 | 90.4 | 82.6-99.0 | ||||
HER2-positive | cMET | High | 40 | 17 | 55.5 | 40.8-75.4 | 0.530 | 13 | 59.4 | 41.4-85.2 | 0.138 |
Low | 13 | 4 | 0.00 | NA-NA | 1 | 100 | NA-NA | ||||
p-cMET | High | 25 | 15 | 36.5 | 19.5-68.3 | 0.019 | 12 | 52.3 | 33.3-82.2 | 0.014 | |
Low | 28 | 6 | 74.1 | 57.4-95.5 | 2 | 91.7 | 81.3-100 | ||||
Triple receptor-negative |
cMET | High | 38 | 15 | 59.5 | 45.5-77.7 | 0.086 | 13 | 56.1 | 38.0-82.7 | 0.187 |
Low | 26 | 5 | 80.4 | 66.4-97.4 | 5 | 66.2 | 66.2-97.4 | ||||
p-cMET | High | 23 | 9 | 60.9 | 43.9-84.5 | 0.251 | 9 | 58.8 | 41.1-84.1 | 0.128 | |
Low | 41 | 11 | 72.3 | 59.6-87.7 | 9 | 74.2 | 60.5-91.0 |
CI: Confidence Interval, cMET: Total cMET, p-cMET: Phospho-cMET