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. Author manuscript; available in PMC: 2013 Nov 9.
Published in final edited form as: Compr Physiol. 2012 Jul;2(3):10.1002/cphy.c110051. doi: 10.1002/cphy.c110051

Figure 7.

Figure 7

Voltage dependence of connexin channels. Upper left panel shows the current elicited by imposing a plus or minus 100 mV gradient across Cx43 channels. The initial current that decays over time until it reaches a lower steady-state current. Right panel shows a plot of the fractional conductance (steady-state conductance (Gss) divided by the initial conductance (Gi)] as a function of transjunctional voltage for Cx40, Cx43, and Cx45. Lower left panel demonstrates the concept of gating polarity of Cx43 (negative gating polarity). If the voltage gradient is sufficiently large the gating particle will close the connexion that is relatively negative on the cytoplasmatic side. Figure adapted from Moreno AP, Biophysical properties of homomeric and heteromultimeric channels formed by cardiac connexins, Cardiovasc.Res., 2002, 62(2):276-86, (448) by permission of Oxford University Press.