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Role of ubiquitination in trafficking and degradation of Cx43. The left cell summarizes the events of polyubiquitination followed by ERAD. The right cells summarizes internalization and lysosomal degradation after Cx43 monoubiquitination. Reprinted from Cell Signal., Vol 22, Kjenseth A, Fykerud T, Rivedal E, Leithe E, Regulation of gap junction intercellular communication by the ubiquitin system, 1267-73, Copyright [2010] (317), with permission from Elsevier.
