. Author manuscript; available in PMC: 2014 Oct 18.

Published in final edited form as: ACS Chem Biol. 2013 Sep 9;8(10):2322–2330. doi: 10.1021/cb400541z

Table 1.

Putative functions of the genes in the 1 biosynthetic pathway and identified metabolites from single-gene knockout strains.^*

Gene	Function	Identified metabolites from KO strains
gsfA	NR-PKS (SAT-KS-AT-PT-ACP)	None^*
gsfB	(3-OH) O-methyltransferase	5, 7, 8, 9
gsfC	(9-OH), O-methyltransferase	6, 16, 17
gsfD	(5-OH), O-methyltransferase	13, 14, 15
gsfE	short-chain dehydrogenase/reductase	18, 19
gsfF	cytochrome P450	10, 11, 12
gsfI	halogenase	2 ^*
gsfK	ketoreductase	1, 2

Knockout of gsfA and gsfI was reported in a previous study by our group (ref 17).