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Oncogenes in PDAC: genetic aberration percentual and type.
| Molecular target | Genetic aberration (%) | Type aberration |
|---|---|---|
| EGFR | 43%–69% | overexpression |
| VEGF | 93% | overexpression |
| KRAS | 90% | point mutation |
| BRAF | 30% | point mutation |
| AKT2 | 15% | amplification |
| MYB | 10% | amplification |
| IGF-1R | 64% | amplification |
| MMPs | 85% | amplification |
| Hedgeogh | 70% | amplification |
| m-TOR | 65% | overexpression |
| MEK | 72% | point mutation |
| COX-2 | 67%–90% | point mutation |
