Table 3.
Human cartilage QconCAT signature peptides in QconCat context order. The three amino acids found adjacent to the N and C termini of the Q-peptide within the native protein are indicated (Matrix metalloproteinase (MMP), collagen (Col), a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), tissue inhibitor of metalloproteinase (TIMP)).
| Peptide order | Protein | Protein Accession | Q-peptide amino acid sequence |
|---|---|---|---|
| 1 | MMP16 | ENSP00000286611 | GIPESPQGAFVHK |
| 2 | MMP16 | ENSP00000286611 | EGHSPPDDVDIVIK |
| 3 | CathepsinD | ENSP00000236671 | LVDQNIFSFYLSR |
| 4 | COMP | ENSP00000222271 | DTDLDGFPDEK |
| 5 | Col11a2 | ENSP00000372565 | LGVPGLPGYPGR |
| 6 | Fibromodulin | ENSP00000347041 | IPPVNTNLEN LYLQGNR |
| 7 | MMP3 | ENSP00000299855 | IVNYTPDLPK |
| 8 | ADAMTS1 | ENSP00000284984 | DAEHYDTAILFTR |
| 9 | ADAMTS4 | ENSP00000356975 | FVETLVVADDK |
| 10 | CathepsinD | ENSP00000236671 | YSQAVPAVTEGPIPEVLK |
| 11 | Link protein | ENSP00000274341 | GGSDSDASLVITDLTLEDYGR |
| 12 | MMP3 | ENSP00000299855 | YLENYYDLK |
| 13 | ADAMTS5 | ENSP00000284987 | GLVQNIDQLYSGGGK |
| 14 | TIMP3 | ENSP00000266085 | WDQLTLSQR |
| 15 | TIMP4 | ENSP00000287814 | GHLPLR |
| 16 | CathepsinK | ENSP00000271651 | SNDTLYIPEWEGR |
| 17 | Link Protein | ENSP00000274341 | FYYLIHPTK |
| 18 | COMP | ENSP00000222271 | SSTGPGEQLR |
| 19 | Plasminogen | ENSP00000308938 | HSIFTPETNPR |
| 20 | MMP13 | ENSP00000260302 | LHPQQVDAELFLTK |
| 21 | MMP13 | ENSP00000260302 | SYYHPTNLAGILK |
| 22 | Plasminogen | ENSP00000308938 | EAQLPVIENK |
| 23 | Col9a1 | ENSP00000349790 | VVGSATLQVAYK |
| 24 | TIMP4 | ENSP00000287814 | LEANSQK |
| 25 | MMP1 | ENSP00000322788 | DGFFYFFHGTR |
| 26 | ADAMTS1 | ENSP00000284984 | GPEVTSNAALTLR |
| 27 | ADAMTS4 | ENSP00000356975 | NPVSLVVTR |
| 28 | Aggrecan | ENSP00000268134 | LEGEVFFATR |
| 29 | Fibromodulin | ENSP00000347041 | LYLDHNNLTR |
| 30 | TIMP1 | ENSP00000218388 | GFQALGDAADIR |
| 31 | TIMP1 | ENSP00000218388 | FVGTPEVNQTTLYQR |
| 32 | TIMP3 | ENSP00000266085 | YQYLLTGR |
| 33 | Col11a2 | ENSP00000372565 | VARPAQLSAPTR |
| 34 | ADAMTS5 | ENSP00000284987 | LPLAAVGPAATPAQDK |
| 35 | Aggrecan | ENSP00000268134 | EVVLLVATEGR |
| 36 | CathepsinK | ENSP00000271651 | VGPVSVAIDASLTSFQFYSK |
| 37 | Col2a1 | ENSP00000338213 | GAQGPPGATGFPGAAGR |
| 38 | Col2a1 | ENSP00000338213 | GPPGPQGAR |
| 39 | Col9a1 | ENSP00000349790 | GVQGEQGATGLPGVQGPPGR |
| 40 | MMP1 | ENSP00000322788 | SQNPVQPIGPQTPK |